PL ISSN 0137-5083
Alkylation of Carbonyl Compounds through Conversion into Oxycyclopropane Intermediates
Influence of Bridging Function of Non-Linear Pseudohalides on Magnetism of Their Metal Complexes
Mrozinski J., Kohout J. and Hvastijova M.
Syntheses and Properties of µ-2-Bromoterephthalato Manganese(II) Binuclear Complexes
Shi J.M., Liao D.Z., Cui J.Z., Jiang Z.H. and Wang G.L.
The CuGaSe2-CdSe Section of the Quasiternary Cu2Se-CdSe-
Olekseyuk I.D., Kadykalo E.M. and Zmiy O.F.
Phase Equilibria in the V2O5-Fe2WO6 System
Walczak J., Rychlowska-Himmel I. and Blonska-Tabero A.
Peptide Synthesis with the Use of N,N'-Dicyclopentylcarbodiimide
Izdebski J., Orlowska A., Pachulska M. and Witkowska E.
3,3-Diarylphthalides. Part I. Friedlaender Reaction of 3'-Alkylphenolphthaleins
Design and Synthesis of New Bradykinin Antagonists with N-Terminal Acylation
Prahl A., Wierzba T., Wszedybyl M., Juzwa W. and Lammek B.
Synthesis and Antibacterial Activity of Novel 1-Butyl-2-phenoxy/2-Phenylthio/2-Amino-|
methyl-5- methoxyindole Derivatives
Gadaginamath G.S. and Patil S.A.
Antagonists of Bradykinin Modified with Conformationally Restricted Dipeptide Fragment
Prahl A., Wierzba T., Winklewski P., Musial P., Juzwa W. and Lammek B.
From Sugar Allyltins to Chiral Cyclopentadienes: Radical Cyclization of Highly Oxygenated Sugar-Derived
Mach M. and Jarosz S.
Zinc Chloride Catalyzed Ring Opening of 3-Mono- and 3,3-Disubstituted Glycidonitriles by Means of Acetyl
Zdrojewski T., Fedorynski M. and Jonczyk A.
Pentad Distribution of Acrylic Copolymers by 13C NMR Spectroscopy
Polymerization of Propylene Oxide on Anatase Surface
Chernyavskaya T.V., Brei V.V., Grebenyuk A.G., Dzyubenko L.S. and Chuiko A.A.
Influence of Na+ Ions on the Specific Surface Area of MgO Catalysts and Their Activity in
Oxidative Coupling of Methane
Ignaczak W., Jozwiak W.K., Gebauer D.T. and Paryjczak T.
Selected Problems Related to Polymeric Electrolytes from the PEO-H3PO4 System
Przyluski J., Zalewska A., Maron J. and Wieczorek W.
Effect of Addition of LiCl on Reaction Rates in Dehydrocoupling of Hydrosilanes with|
Hydroxyl Containing Nucleophiles, in DMF Catalyzed by ZnCl2
Osmium(VIII) Catalyzed Oxidation of Allyl Alcohol by N-Bromosuccinimide in Aqueous |
Chougale R.B., Kamble D.L. and Nandibewoor S.T.
Transport Properties of Nonstoichiometric Manganous Sulphide
Mrowec S., Danielewski M. and Wojtowicz A.
CRYSTAL AND MOLECULAR STRUCTURES
The Structure of 3-[4-(4-Phenylpiperazine)butyl]-5,5-diisopropylhydantoin - New Ligand of Serotonin
Wolska I., Byrtus H. and Zejc A.
Bicyclic [b]-Heteroannelated Pyridazine Derivatives. 7. Structure of O-benzyl-8-phenyl-3-
Karolak-Wojciechowska J., Lange J. and Trzezwinska H.B.
Structure and Magnetism of Nickel(II) Dimer with Thiourea Bridges
Melnik M., Sramko T., Dunaj-Jurco M., Jorik V., Kalinska B. and Mrozinski J.
An Expedient Differentiation between Substituted 1,3-Oxazolane and 1,3-Dioxane Moieties by Mass
Achmatowicz O., Baranowska E. and Szechner B.
IUPAC Recommendations on Nomenclature and Symbols.
Alkylation of Carbonyl Compounds through
by O.G. Kulinkovich
(Received December 31st, 1996; revised manuscript February 24th, 1997)
Alkylation of carbonyl compounds through their conversion into the corresponding oxycyclopropane intermediates followed by a three-carbon atom ring cleavage is reviewed.
Influence of Bridging Function of Non-Linear
by J. Mrozinski1, J. Kohout2 and M. Hvastijova2
(Received February 20th, 1997)
Temperature-dependent magnetic properties (4.2-300 K) of a series of pseudohalide metal complexes with organic nitrogen ligands of the type ML2X2, where M = Cu, Ni, Co; L = pyrazole, imidazole or pyridine type ligand; X = [C(CN)3]-, [N(CN)2]- , [C(CN)2,NO]- are reviewed. Three types of µeff vs. T functions were ascertained and discussed in terms of both ferro- and antiferromagnetic interactions, which operate between the Cu(II) atoms through orbitals of the bridging pseudohalides. The theory of Kahn et. al. is applied to understand the complex magnetic behaviour of these compounds.
Syntheses and Properties of µ-2-Bromoterephthalato Manganese(II) Binuclear Complexes
by J.M. Shi, D.Z. Liao, J.Z. Cui, Z.H. Jiang and G.L. Wang
(Received February 7th, 1997; revised manuscript March 13th, 1997)
Three new manganese(II) binuclear complexes: [Mn2(BTPHA)(Phen)4](ClO4)2 (1), [Mn2(BTPHA)(Nphen)4](ClO4)2 ·H2O (2), [Mn2(BTPHA(Bpy)4](ClO4)2·H2O (3), (BTPHA = 2-bromoterephthalate, Phen = 1,10-phenanthroline, Nphen = 5-nitro-1,10-phenanthroline, Bpy = 2,2-bipirydyl), have been synthesized with 2-bromoterephthalato as the bridged ligand, and were characterized by elemental analysis, IR, molar conductance and electronic reflection spectra. They are proposed to have an extended 2-bromoterephthalato-bridged structure and to consist of two manganese(II) atoms. The variable-temperature magnetic susceptibility of complex 1 was measured over 4.2-300 K. The magnetic coupling parameter is consistent with an antiferromagnetic exchange between the two manganese(II) centers and fits the data with binuclear magnetic exchange model based on the Hamiltonian operator (H=- 2JS1S2, S1 = S2 = 5/2), giving the antiferromagnetic coupling parameter of 2J = -2.3 cm-1.
The CuGaSe2-CdSe Section of the Quasiternary
by I.D. Olekseyuk, E.M. Kadykalo and O.F. Zmiy
(Received January 21st, 1997; revised manuscript March 18th, 1997)
The interaction of copper selenogalate with cadmium selenide was investigated using differential thermal, microstructural and X-ray analyses. Polythermal CuGaSe2-CdSe section of the quasiternary Cu2Se-CdSe-Ga2Se3 system has been constructed. The existence of an intermediate delta-phase and solid solutions has been established.
Phase Equilibria in the V2O5-Fe2WO6System
by J. Walczak, I. Rychlowska-Himmel and A. Blonska-Tabero
(Received December 23rd, 1996; revised manuscript April 14th, 1997)
Using DTA and X-ray phase diffraction methods, a diagram of phase equilibria in V2O5-Fe2WO6 system has been constructed. This system is not a real binary system, even below the solidus line.
Peptide Synthesis with the Use of
by J. Izdebski, A. Orlowska, M. Pachulska and E. Witkowska
(Received February 14th, 1997)
The usefulness of N,N'-dicyclopentylcarbodiimide as a coupling reagent for solid phase peptide synthesis was demonstrated by the synthesis of sequences comprising the 65-74 residues of acyl carrier protein. The result was compared with that obtained using N,N'-dicyclohexylcarbodiimide and N-cyclohexyl-N'- isopropylcarbodiimide. The title compound was also used for synthesis of [Nle27]GH-RH(1- 29)NH2. All coupling steps were monitored with quantitative ninhydrin test. It is concluded that this new reagent can be successfully used for solid phase peptide synthesis.
3,3-Diarylphthalides. Part I.
by J.K. Ruminski
(Received January 2nd, 1997; revised manuscript February 27th, 1997)
Friedlaender reaction was investigated, starting from 3'-alkyl-derivatives of phenolphthalein 1- 3 (alkyl = Me, Et and i-Pr) and hydroxylamine in strongly alkaline medium. The process was found to give, after acidic hydrolysis of primarily formed anil-type semi-products, a mixture of two 2-aroylbenzoic acids (2-ABAs) in each case. Identification and quantification of 2-ABAs were carried out within RP-HPLC on ODS column. Based on quantitative results, migratory aptitude (MA) parameter values of ionized 4-hydroxy-3- alkylphenyl nuclei were calculated, taking an unsubstituted ionized 4-hydroxyphenyl ring as a standard.
Design and Synthesis of New Bradykinin
by A. Prahl1, T. Wierzba2, M. Wszedybyl2, W. Juzwa2 and B. Lammek1
(Received November 15th, 1996; revised manuscript March 3rd, 1997)
Synthesis and some pharmacological properties of eight new analogues of bradykinin are described. Five peptides were designed to gain more information about features of N-terminal bulky acyl groups suitable for improvement of B2-antagonistic properties. Two other compounds were synthesized in order to learn how removal of N-terminal D-Arg residue or replacement of D-Arg-Arg with a Lys-Lys fragment would influence B2-antagonism. The last peptide was obtained in order to check whether inversion of configuration of C-terminal Arg residue in the molecule of potent B2-blocker will decrease its antagonistic activity. The B2-antagonistic potency of analogues was evaluated by their ability to inhibit vasodepressor response to exogenous bradykinin in conscious rats. Thus it appears that not only the size of an acyl group attached to the N-terminus of peptide, but also chemical features of the substituent are important for B2-antagonism.
Synthesis and Antibacterial Activity of Novel
by G.S. Gadaginamath and S.A. Patil
(Received June 4th, 1996; revised manuscript March 3rd, 1997)
6-Bromo-2-bromomethyl-1-butyl-3-ethoxycarbonyl-5-methoxy-indole (2) was prepared from 2- methylindole derivative 1 using NBS as regioselective brominating agent. Compound 2 was then reacted with different nucleophiles: phenols, thiophenols and amines to yield the corresponding phenoxy, phenylthio and aminomethylindole derivatives. All new compounds were screened for antibacterial activity.
Antagonists of Bradykinin Modified with
by A. Prahl1, T. Wierzba2, P. Winklewski2, P.
(Received February 10th, 1997; revised manuscript March 10th, 1997)
Four new analogues of bradykinin (BK) were designed, synthesized and bioassayed. The analogues were designed by introduction of the conformationally restricted dipeptide fragment D-Phe-D-Phe into positions 6, 7 or 7, 8 of an previously synthesized antago-nist. The antagonistic potency of peptides was assessed by their ability to inhibit vasodepressor response to exogenous bradykinin in conscious rats. We proved the importance of appropriate localization of the modification used in the molecule for the value of antagonistic activity. We also demonstrated that acylation of the N-terminus of the new analogues with 1-adamantaneacetic acid did not increase, as previously considered, antagonistic potencies of the resulting peptides. Our study, besides providing new information about the structure-activity relationship of bradykinin antagonists, resulted in compounds, which may be useful for clarifying the role of BK in various physiological effects.
From Sugar Allyltins to Chiral Cyclopentadienes:
by M. Mach and S. Jarosz
(Received March 12th, 1997)
Radical cyclization of unsaturated aldehyde: 2,3,4-tri-O-benzyl-5,6,7,8-tetradeoxy- -5(E),6-dieno-oct-D- xylose (2) afforded 1(R)-hydroxy-2(S),3(S),4(R)-tri-O-benzyloxy-5(R)-[prop-1(E)-enyl]-cyclopentane (5); similar reaction of xanthate 7 derived from 2 led to 2(S),3(R),4(R)-tri-O- benzyloxy-5(R)-methyl-cyclopentane (8). The cyclization of other sugar-derived unsaturated aldehydes and xanthates was also studied.
Zinc Chloride Catalyzed Ring Opening of 3-Mono-
by T. Zdrojewski, M. Fedorynski and A. Jonczyk
(Received February 27th, 1997; revised manuscript March 25th, 1997)
Glycidonitriles 1a-e, when treated with acetyl chloride in the presence of catalytic amounts of zinc chloride, afforded mixtures of chloroacetoxynitriles 2 and acetoxycyanoalkenes 4. Isolated nitriles 2 treated with triethylamine transform into substituted acetoxyacrylonitriles 3.
Pentad Distribution of Acrylic Copolymers
by M. Matlengiewicz
(Received February 10th, 1997; revised manuscript March 26th, 1997)
The carbonyl signal of the 100 MHz 13C NMR spectrum of methacrylate/acrylate copolymers provides sufficient resolution for detailed analysis of sequence distribution up to configurational-compositional pentads. It has been shown for the investigated methyl methacrylate/ethyl acrylate copolymer, MMA/EA, that the spectrum of carbonyl region can be positively simulated by applying Bernoulli/1st order Markov statistics to calculate the sequence intensities and a method of incremental calculation of chemical shift to determine the line positions. The method may be readily adopted for other acrylate/methacrylate copolymer systems.
Polymerization of Propylene Oxide
by T.V. Chernyavskaya, V.V. Brei, A.G. Grebenyuk,
(Received July 12th, 1996; revised manuscript April 4th, 1997)
The polymerization of propylene oxide on the surface of thermoactivated anatase has been studied by infrared spectroscopy, thermal gravimetry, field ionization mass spectrometry, and quantum-chemical simulation. Data are given upon the dependence of the grafted oligomer mass on the temperature of the preliminary treatment of anatase surface. The coordination mechanism of the propylene oxide polymerization with the participation of Ti4+ ions of the TiO2 matrix is discussed.
Influence of Na+ Ions on the Specific Surface Area
by W. Ignaczak, W. K. Jozwiak, D.T. Gebauer and T. Paryjczak
(Received January 30th, 1997)
Results concerning the influence of calcination conditions and Na+ ions addition on the specific surface area of MgO using BET and XRD techniques are presented. Na+ ions cause the sintering process of MgO - a considerable loss of surface area and structural changes in MgO lattice. Na+/MgO doped catalysts were active and selective for C2 hydrocarbons formation, especially above 950 K.
Selected Problems Related to Polymeric Electrolytes
by J. Przyluski, A. Zalewska , J. Maron and W. Wieczorek
(Received November 29th, 1996; revised manuscript January 30th, 1997)
Protonic electrolytes from the PEO-H3PO4 system are studied by impedance and Fourier transform infrared spectroscopies and differential scanning calorimetry. Different conduction mechanisms are found depending on the concentration of H3PO4 and are discussed on the basis of the experimental data.
Effect of Addition of LiCl on Reaction Rates
by J. Chrusciel
(Received October 16th, 1996; revised manuscript February 3rd, 1997)
The addition of LiCl causes a decrease in reaction rate and even inhibition of dehydrocoupling of organic hydrosilanes (Et3SiH and Me2PhSiH) with Ph3SiOH, Ph2Si(OH)2, MeOH, and PhCOOH, when carried out in DMF in the presence of ZnCl2. The rate constants are proportional to the difference in the catalyst and LiCl concentrations, due to the effect of addition of a common anion on the dissociation equilibria. The driving force for the reaction is an electrophilic assistance of the active form(s) of the catalyst (most likely Zn2+) to the cleavage of the SiH bond in the rate determining step, while the interaction of chloride anion Cl- with silicon in H-silanes does not play any role in the reaction mechanism. This is a new example of the mechanism of the nucleophilic substitution of hydrosilanes with reagents containing a hydroxyl group, because of zero order of the reaction with respect to OH group.
Osmium(VIII) Catalyzed Oxidation of Allyl Alcohol by N-Bromosuccinimide in Aqueous Alkaline Medium
by R.B. Chougale, D.L. Kamble and S.T. Nandibewoor
(Received October 9th, 1996; revised manuscript February 7th, 1997)
The osmium(VIII) catalyzed oxidation af allyl alcohol by N-bromosuccinimide in alkaline medium is first order each in [N-bromosuccinimide] and [osmium(VIII)], whereas fractional order each in [allyl alcohol] and [alkali]. Increase in [alkali] increases the rate, while added succinimide retards the reaction. Negligible effect of dielectric constant and ionic strength on the reaction medium has been observed. A mechanism involving hypobromite ion, as the reactive species of the oxidant has been proposed. The reaction constants of individual steps of the reaction mechanism have been evaluated.
Transport Properties of Nonstoichiometric
by S. Mrowec, M. Danielewski and A. Wojtowicz
(Received February 21st, 1997; revised manuscript March 24th, 1997)
The chemical diffusion coefficient in non-stoichiometric manganous sulphide, Mn1-yS, has been
measured as a function of temperature (1073-1373 K) and sulphur activity (10-2-
103 Pa) using electrical conductivity reequilibration method. It has been shown that the mobility
of doubly ionized cation vacancies, constituting the predominant point defects in Mn1-yS, is
independent of their concentration and characterized by the following empirical relationship: Dv =
1.3· 10-2exp((76.4+/-0.5 kJ mol-1)/(RT)).
The Structure of 3-[4-(4-Phenylpiperazine)butyl]-
by I. Wolska1, H. Byrtus2 and A. Zejc2
(Received January 31st, 1997)
The crystal structure of 3-[4-(4-phenylpiperazine)butyl]-5,5-diisopropylhydantoin has been determined by X- ray diffraction methods. Compound crystallizes in a monoclinic system, space group P21/n with a = 12.943(2), b = 8.514(2), c = 21.746(2) Å, ß = 103.96(1)o, V = 2325.6(7) Å3. The piperazine ring adopts a chair conformation. The phenyl ring and the mean piperazine plane are close to coplanarity. The molecules form centrosymmetric dimers by means of the intermolecular hydrogen bonds N-H···O.
Bicyclic [b]-Heteroannelated Pyridazine Derivatives. 7.
by J. Karolak-Wojciechowska1, J. Lange2 and H.B. Trzezwinska1
(Recived February 6th, 1997; revised manuscript March 10th, 1997)
The structure of O-benzyl-7,8-dihydro-8-phenyl-3-trifluoromethyl-
Structure and Magnetism of Nickel(II) Dimer
by M. Melnik1, T. Sramko1, M. Dunaj-Jurco1, V.
(Received March 21st, 1997)
The crystal lattice of the title red-brown compound contains dimeric [Ni2(tu)8Br2]2+ cations and NO3- anions. The cations consist of symmetrically bridged S atoms of thiourea with Ni-S bridging distance of 2.47 Å, the Ni-Ni distance of 4.04 Å, and the bridging angle of 104o. Each nickel(II) atom has a distorted octahedral S5Br coordination sphere. The susceptibility data for powder, determined betwen 4.2 and 295 K, show the existence of antiferromagnetic intradimer interaction between the nickel(II) centers.
An Expedient Differentiation between Substituted
by O. Achmatowicz, E. Baranowska and B. Szechner
(Received March 18th, 1997)
IUPAC Recommendations on Nomenclature and Symbols
Nomenclature, symbol, units and their usage in spectrochemical analysis -
Laser-based Molecular Spectrometry for Chemical Analysis - Luminescence
Revised section F: natural products and related compounds
Glossary of terms used in medicinal chemistry
(IUPAC Recommendations 1996)
Nomenclature, symbol, units and their usage in spectrochemical analysis - XIV
Laser-based molecular spectroscopy: proposal for a new notation
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© 1997 Polish Journal of Chemistry
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